Verb Formation in Angkola Language

This study deals with the verb formation in Angkol language. This study aims tofind out the kind of affix that formed a verb in Angkola, to describethe pattern ofverb formation in Angkola language and also to find out the grammaticalmeanings occurred through the verb formation in Angkola language. This studywas conducted by using descriptive qualitative method by Moleong (1975:5).Inthis research, the descriptive qualitative method was used to find out the types ofaffixes that formed a verb in Angkola language and to describe the pattern of verbformation in Angkola language. The data of this research were taken from thescript of Parhuta-huta part I movie, and 8 song lyrics of Top SimamoraftDeliana.The technique of data analysis applied was generative morphology proposed byHalle (1973). After analyzing the data it was found that were three kinds of affixesfound in verb-formation of Angkola language, namely: 1). Prefix, such as [di-],[ma-], [mar-], [tar], [pa], [maN-]. 2). Suffix, such as: [-kon], [-i], [-hon]. 3).Confix, such as: [maN-i], [maN-kon] and [mar-an], and morphophonemic changealso occurred through the verb formation of Angkola language, namely: 1).Phonological alteration (assimilation) and 2). Phonological Deletion (Omission).And also found four kinds of grammatical meaning occurred through the verbformation of Angkola language namely: 1. activity, 2. Process, 3. Command, 4.Condition. Therefore the dominant types of affixes occurred in verb formation ofAngkola language is prefix with 6 kinds of prefixes. The findings of this researchshowed that verbs can be formed through a process of affixation whether it comesfrom the verb, noun, adjective, adverbial

Analisis Profitabilitas pada PT. Alwan Zahira Tahun 2010-2012 di Samarinda

Profitability is the ratio which aims to determine the company's ability to generate profits for a certain period and also give an idea of the effectiveness of management in their operation.The problems of this paper is formulated ; Profitability is at. Alwan Zahira has increased from year 2010-2012 ? By hypothesis Profitability at. Alwan Zahira from 2010 to 2012 has increased. The purpose of this study was to determine the level of profitability. The purpose of this study was to determine the level of profitabitas at. Alwan Zahira in Samarinda from 2010-2012.Basic theory used is financial management by using tools of analysis and hypothesis testing are: Gross Profit Margin , Operating Profit Margin , Net Profit Margin, Return On Investment ( ROI ) and Total Assets Turn Over .Based on these discussions , it is generally known that the ratio of profitability at PT . Alwan Zahira tend to fluctuate from year 2010-2012 , so in this case the authors hypothesis is rejected , given the proposed hypothesis is the author of " Profitability in PT. Alwan Zahira from 2010 to 2012 has increase

Synergistic Anti-Candida Activity of Bengazole A in the Presence of Bengamide A †.

Bengazoles A⁻G from the marine sponge Jaspis sp. exhibit potent in vitro antifungal activity against Candida spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in Candida albicans under both liquid culture and surface culture on Mueller-Hinton agar. Pronounced dose-dependent synergistic antifungal activity was observed with bengazole A in the presence of bengamide A, which is also a natural product from Jaspis sp. The MOA of bengazole A was further explored by monitoring the sterol composition of C. albicans in the presence of sub-lethal concentrations of bengazole A. The GCMS of solvent extracts prepared from liquid cultures of C. albicans in the presence of clotrimazole-a clinically approved azole antifungal drug that suppresses ergosterol biosynthesis by the inhibition of 14α-demethylase-showed reduced cellular ergosterol content and increased concentrations of lanosterol and 24-methylenedihydrolanosterol (a shunt metabolite of ergosterol biosynthesis). No change in relative sterol composition was observed when C. albicans was cultured with bengazole A. These results eliminate an azole-like MOA for the bengazoles, and suggest that another as-yet unidentified mechanism is operative

Analisis Kepuasan Mahasiswa Stain Kudus Dalam Perspektif Islam

This article is meant to analyze the influence of service quality variables; tangible, reliability, responsiveness, assurance and empathy toward students satisfaction. Samples of this study are 70 students of Kudus State Islamic College taken by probability sampling method and cluster random sampling method. The data are analyzed using multiple linear regressions. Result of this study shows that variable of tangible, reliability, responsiveness, and assurance partially have significant effect toward student satisfactions. Secondly, together, those five variables have significant effects toward student satisfaction

Structural and Functional Studies of Proteins Involved in Antigen Processing: A Dissertation

This thesis is comprised of studies of proteins involved in class I and class II major histocompatibility complex (MHC) antigen procressing. In class I MHC processing, structural and functional studies were conducted of an aminopeptidase, ERAP1, that mediates the final step in antigen processing to understand how it is particularly suitable for cleavage of antigenic peptides for class I MHC presentation. In the class II MHC antigen presentation pathway, structural studies were conducted to characterize a fluorogenic peptide that can be used to understand peptide loading events in vivo and in real time. Also structural studies of class II MHC and peptide complexes were conducted to understand the nature of an unique C-terminal secondary structure element exhibited by an HIV derived peptide in the peptide binding groove of class II MHC. The studies discussed in this thesis provide insights into the proteins involved in the class I and class II MHC antigen presentation pathway. The endoplasmic reticulum (ER) aminopeptidase, ERAP1, is a 941 amino acid member of the M1 family of zinc metalloaminopeptidases. Unlike other aminopeptidases, ERAP1 has a length and C-terminal preference for its substrates. Interestingly, ERAP1 has been shown to trim antigenic peptides to lengths of 8 or 9 amino acids long. This length matches the length required to bind into the peptide binding groove of class I MHC molecules. In addition, ERAP1 is upregulated in the ER of cells treated with interferon gamma (IFN-γ). Knock-down of ERAP1 by siRNA results in less overall antigenic presentation during IFN-γ treatment, although the knock-down does not affect all class I MHC epitopes equally. Knock-out studies show that ERAP1 effects the antigen repertoire at the cell surface. These and other data implicate ERAP1 as an important player in class I MHC antigen presentation. A chapter of this thesis will describe the crystallographic work describing the structures of ERAP1 with an aminopeptidase inhibitor, bestatin, and ERAP1 without an inhibitor that suggest possible peptide binding site in ERAP1 that will allow it to generate suitable substrates for a subset of class I MHC alleles. Class II MHC plays a key role in the immune response by presenting antigenic peptides on CD4+ cytotoxic cell surfaces for T-cell response. The binding of peptides onto the MHC is an important step in creating an immune response. Structures of peptide bound MHC class II show conserved side chain binding pockets within the overall peptide-binding groove. In HLA-DR1, a common human class II MHC, the P1 pocket shows a preference for large hydrophobic side chains. Development of environmentally sensitive peptide analogs, that can bind into the class II MHC the same way as native peptides, can assist in visualizing the antigen binding process. A chapter in this thesis describes the crystallographic work showing that (4-DAPA)-HA can be used to study antigen-presenting processes in a cell by visualizing the changes in fluorescence of the synthesized peptide upon antigen loading. Crystallographic analysis of MHC class II, HLA-DR1, in complex with HIV gag-derived peptide, GagP16(PEVIPMFSALSEGATP), and superantigen, SEC3- 3B2, reveals the conventional polyproline conformation up to MHC binding pocket residue, P9, while the C-terminus of GagP16 adopts an unusual β- hairpin loop structure. Additionally, interactions between the leucine at P8 (LeuP8) and other residues on the loop such as ThrP16 and AlaP14 of the hairpin loop, was observed. Importantly, GagP16 requires the last 4 amino acids (P13-P16), which is part of the hairpin loop, for T-cell recognition. Understanding what dictates the C-terminal hairpin loop and the interaction motif of HLA-DR1/GagP16 complex with its TCR will provide insights on why it is important for T cell activation. A chapter in this thesis discusses the structural investigation conducted to understand the determinants of the loop at the C-terminus of GagP16 using designed peptides. It will also discuss work involving HLA-DR1 with the T cell receptor, AC25, that was cloned from T cells that are specific to HLA-DR1 in complex with the GagP16 peptide

Increasing Efficiency in the Construction Industry and Construction Management Classrooms Using Computer Software

The purpose of this research is to identify the best computer software programs that are the most effective within the construction industry. Companies are gradually shifting from manual practices to various software and technologies to optimize business and communication efficiency. With the plethora of software available, the industry does not fully understand which software are the most effective for addressing the challenges of the industry. As the industry is struggling with integrating these software into their company structure, more money is being spent to tackle the challenges that face the construction industry today. Companies that do not integrate construction technology to further their efficiency will be left behind. Industry productivity reports show that the construction industry has lost productivity since the 1950\u27s while other industrial sectors have increased their productivity using modem technology. (Crumrie, 2017). Most construction companies work through their management processes manually, instead of utilizing available software programs like Procore, Bluebeam, ASTA Powerproject, and ProEst. These programs are designed to increase efficiency and productivity. In this paper, data is collected and analyzed from Fortune 500 companies, such as Lithko Contracting LLC, Bulley & Andrews, Hensel Phelps, NECA, Walsh and others, and their representatives, regarding their technology usage. The data is taken from company Vice Presidents, Project Managers, Supervisors, and Project Engineers. Application software for various construction management practices are examined and evaluated for their production efficiency impact and relative cost